Roots of Depression

One of the extremely complicated diseases affecting the population nowadays is ‘DEPRESSION’. Though the majority of the population seems affected by this; the roots of this disease remain covered in some cases. People fail to realize the causes of their depressed condition, but the complex problem can arise due to various reasons.

Causes of depression:

There exist several factors that can cause distress or increase the probability of its occurrence. Some of these are:


The emotional, sexual or physical abuse in the past makes the person more vulnerable to depression in his later life.

Death or physical loss

The sudden death or physical damage of near ones increases grief and sadness which in turn can make the person more prone to depression.


There are certain drugs like corticosteroids, antiviral drugs, and drugs which help in curing acne; these drugs can heighten the person’s risk of suffering from depression.


The people who are biologically more vulnerable to develop this mental disorder increase their chances of heightening it if there occurs any case of dispute or disagreement with close friends or near ones.

Major events—

Sometimes, good events like getting married, graduating or starting a new job can cause depression. Again, retiring from a job, losing income or employment, divorce can also lead to the person becoming depressed.

Substance abuse

Substance abuse is known to cause clinical or major depression in nearly 30% of the population. Even though alcohol and drugs provide temporary relief, they are known to aggravate the condition.

The chemistry behind depression:

            How does depression happen?

The chemical imbalances in the brain are known to cause distress; there are several chemicals involved in this activity. These chemicals operate both outsides and inside the nerve cells. Many chemical reactions are happening within the human system that is responsible for their mood fluctuations and their experiences and perceptions. The seat of emotions is present in the brain and specific areas in the brain help to regulate the moods of the human being. Although the levels of these chemicals play a part in heightening the complexities; the growth of the nerve cells, the connection within the nerve cells and the operation of the nerve circuit strongly influence the depressed condition.

Hippocampus, thalamus, and amygdala are parts that play an essential role in causing depression. Depressed people have small hippocampus, and as the bouts of depression increases, the size of this part reduces further. Stress has been directly linked to the sad condition as it suppresses the formation of new nerve cells in the hippocampus. The antidepressant drugs trigger the growth of nerve cells in the hippocampus. Thus it can be said that these antidepressants strengthen the connections among the nerve cells and improve information exchanges within nerve circuits. Hence the medicines that should be administered to cure this complicated situation should promote neuro-genesis. This will assure the patients quicker relief from the painful condition.

Thus, although the causes of depression differ, administering proper medications can help cure this disease. The person should communicate properly about his problems and symptoms so that he gets the apt treatment.

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